http://www.seattlemonorail.com/
Basically, you can catch it at Seattle Center and it goes to Westlake Center (a shopping mall). If you walk out the southern entrance of Westlake, walk one block south and then west--you will see the Pike Place Market. Head south down 1st and you'll come to Pike Brewing.
It's a six-block walk from the monorail, in case you were wondering.