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On that third point... which is important to me personally.
QM (as I recall it) limits our knowledge of a particular particle's location vs momentum. But there is nothing which says that we cannot aim to understand all the rules that relate to that particle.
So I would maintain that it's still a valid goal, for humanity to seek to understand the rules that govern reality. I would suggest that this is supported by the breakthroughs that have occurred since after the uncertainty principle was discovered.
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